[EASD2010]对话EASD主席U. Smith 教授——胰岛素抵抗和糖尿病遗传学研究进展
内容概要：本届EASD主席Ulf. Smith教授是瑞典Gothenburg大学分子与临床医学系和Sahlgrenska大学医院的内科教授，是胰岛素抵抗和2型糖尿病发病机理方面的专家，主要研究领域为脂肪组织在胰岛素抵抗中的作用及增加胰岛素抵抗患者心血管疾病风险的因素。Smith教授在接受《国际糖尿病》采访时详细剖析了EASD2010大会热点、胰岛素抵抗发病机制和2型糖尿病遗传学研究的益处。
International Diabetes：Is it the person who is predisposed to cancer – perhaps because of genetics – who will perhaps develop diabetes， or is it the diabetes itself that brings on the cancer?
国际糖尿病：是易患癌症的人，可能因为遗传的因素，将来可能会发生糖尿病还是糖尿病本身会引起癌症呢？
Dr. Smith：As best we understand it today， it is probably not the genetic background that leads to the increased risk of cancer. It is more likely that the obese type 2 diabetic individual has an environment – for whatever reason – which promotes the growth of cancer cells. That is， at least， what the scientific evidence suggests is very likely the case.
Smith教授：目前我们对于这个问题的理解，是遗传背景可能并不会使癌症的发生风险增加。更有可能的是某个肥胖的2型糖尿病个体体内存在着一种能够促进肿瘤细胞生长的环境，无论是什么原因吧。至少，一些科学证据表明这点是很有可能的。
International Diabetes：Modern research indicates that insulin resistance is one of the most significant mechanisms for type 2 diabetes， that’s elementary; what method do you think would best detect insulin resistance?
国际糖尿病：现代研究表明胰岛素抵抗是2型糖尿病最重要的发病机制之一，也是最基本的；那么您认为什么方法能够及时准确的检测到胰岛素抵抗的发生呢？
Dr. Smith:Again， this is also quite a broad question. But as a scientist I think there is no doubt: the euglycemic hyperinsulinemic clamp where you infuse glucose and insulin and then you can see how much glucose is taken up for a given insulin concentration. But that requires expertise and a laboratory and it is not a practical clinical investigation. Other more easy ways are to look at the fasting insulin level for an individual and if you have some background information of what is “normal”， then you can look at fasting insulin level and get an ide
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